Quelle: Fachblatt The Lancet

Jugendliche die nach ihrer Geburt gestillt wurden haben eine um 14% niedrigere LDL/HDL-Cholesterin-Rate ("böses Cholesterin" im Vergleich zum "guten Cholesterin") als ihre Altersgenossen, die mit industriell gefertigter Babynahrung ernährt wurden.

Dadurch wird das rechnerische Herz-Kreislaufrisiko deutlich erniedrigt. Diese Funde legen die Vermutung nahe, dass die Ernährung im frühesten Kindesalter bereits die Weichen für den Fettstoffwechsel im Erwachsenenalter stellt.

STUDY SUGGESTS BREASTFEEDING REDUCES CARDIOVASCULAR RISK LATER IN LIFE

Lancet 2004; 363: 1571-78; 1642-45

Breastfeeding in infancy is likely to reduce the risk of atherosclerosis-and therefore cardiovascular disease-in adult life, suggest authors of a UK study in this week's issue of THE LANCET.

There are known to be many benefits from breastfeeding, although several previous studies associating breastfeeding with reduced cardiovascular disease in adulthood have been limited by methodological weaknesses, such as retrospective study design. Atul Singhal from the Institute of Child Health, London, UK, assessed prospectively whether preterm infants who were breastfed were less likely to have markers for atherosclerosis than preterm infants given formula milk.

The investigators followed up 216 teenagers (aged 13-16 years) who had been randomised to different milks in two trials for infant nutrition (breastmilk verses preterm formula, and preterm formula verses term formula) in the early 1980s. Among the measures used at follow-up to assess adolescent lipoprotein profile (an indicator of atherosclerosis risk) was the ratio of 'bad' to 'good' (LDL to HDL) cholesterol, and concentrations of c-reactive protein (CRP, higher concentrations are associated with the development of atherosclerosis).

Those adolescents who had been given breastmilk during infancy had a 14% lower ratio of LDL to HDL cholesterol and lower concentrations of CRP than adolescents who had been given formula milk in infancy. A greater proportion of human milk intake in infancy was associated with lower ratios of LDL to HDL cholesterol.

Dr Singhal comments: "The findings of our prospective study suggest that infant nutrition permanently affects the lipoprotein profile later in life, and specifically that breastmilk feeding has a beneficial effect. Furthermore, we have shown a possible benefit of breastmilk compared with formula feeding on later concentration of CRP, a marker of the inflammatory process associated with atherosclerosis and cardiovascular disease...Our findings suggest that breastmilk feeding has a major beneficial effect onlong-term cardiovascular health".

See also Viewpoint: Early origins of cardiovascular disease: is there a unifying hypothesis? (p 1642)

MRC Press Office, T)+44(0)020 7637 6011; E) press.office@headoffice.mrc.ac.uk
Contact: Stephen Cox, Chief Press Officer, Great Ormond Street Hospital for Children NHS Trust and the Institute of Child Health, London, UK; T) +44 (0)20 7829 8671; E) CoxS@gosh.nhs.uk

Issue 15 May 2004
Embargoed 0001 h (London time) 14 May 2004. In North America the embargo for Lancet press material is 6:30pm ET Thursday 13 May 2004.