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Quelle:
Medline Abstract
Herzinfarktrisiko
ist bei Vitamin-D-Mangel deutlich erhöht: an der
Health Professionals Follow-up Study
nahmen
18225 Männer teil. Die Analyse der Vitamin D-Blutwerte zeigte,
dass es auch nach Berücksichtigung anderer Risikofaktoren für
Herzinfarkt eine enge Verbindung zwischen dem Vitamin-Blutspiegel
und dem Herzinfarktrisiko gibt. Vereinfacht gesagt: je höher
der gemessene Vitamin-D-Blutspiegel, um so niedriger das Herzinfarkt-Risiko.
Die
vollständige englischsprachige Kurzversion dieser Studie (sog.
MEDLINE Abstract) finden Sie
hier
25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men
A Prospective Study
Edward Giovannucci, MD, ScD; Yan Liu, MS; Bruce W. Hollis, MD,
PhD; Eric B. Rimm, ScD
Arch Intern Med. 2008;168(11):1174-1180.
Methods We assessed prospectively whether plasma 25-hydroxyvitamin
D (25[OH]D) concentrations are associated with risk of coronary
heart disease. A nested case-control study was conducted in 18
225 men in the Health Professionals Follow-up Study; the men
were aged 40 to 75 years and were free of diagnosed cardiovascular
disease at blood collection.
Results After adjustment for matched variables, men deficient
in 25(OH)D (≤15 ng/mL [to convert to nanomoles per liter,
multiply by 2.496])
were at increased risk for MI
compared with those considered to be sufficient in 25(OH)D (≥30
ng/mL) (relative risk [RR], 2.42; 95% confidence interval [CI],
1.53-3.84; P < .001 for trend).
Even men with intermediate 25(OH)D levels were at elevated risk
relative to those with sufficient 25(OH)D levels (22.6-29.9 ng/mL:
RR, 1.60 [95% CI, 1.10-2.32]; and 15.0-22.5 ng/mL: RR, 1.43 [95%
CI, 0.96-2.13], respectively).
Conclusion Low levels of 25(OH)D are associated with higher
risk of myocardial infarction in a graded manner, even after controlling
for factors known to be associated with coronary artery disease.
Author Affiliations: Departments of Nutrition (Drs Giovannucci
and Rimm and Ms Liu) and Epidemiology (Drs Giovannucci and Rimm),
Harvard School of Public Health, Boston, Massachusetts; Channing
Laboratory, Department of Medicine, Brigham and Women's Hospital
and Harvard Medical School, Boston (Drs Giovannucci and Rimm);
and Department of Pediatrics, Medical University of South Carolina,
Charleston (Dr Hollis).
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