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Herzinfarktrisiko ist bei Vitamin-D-Mangel
deutlich erhöht: an der
Health Professionals Follow-up
Study
nahmen
18225 Männer teil. Die Analyse der Vitamin
D-Blutwerte zeigte, dass es auch nach
Berücksichtigung anderer Risikofaktoren für
Herzinfarkt eine enge Verbindung zwischen dem
Vitamin-Blutspiegel und dem
Herzinfarktrisiko gibt. Vereinfacht gesagt: je
höher der gemessene Vitamin-D-Blutspiegel, um so
niedriger das Herzinfarkt-Risiko.
Die vollständige englischsprachige
Kurzversion dieser Studie (sog. MEDLINE
Abstract) finden Sie
hier
25-Hydroxyvitamin D and Risk of Myocardial
Infarction in Men
A Prospective Study
Edward Giovannucci, MD, ScD; Yan Liu, MS; Bruce
W. Hollis, MD, PhD; Eric B. Rimm, ScD
Arch Intern Med. 2008;168(11):1174-1180.
Methods We assessed prospectively whether plasma
25-hydroxyvitamin D (25[OH]D) concentrations are
associated with risk of coronary heart disease.
A nested case-control study was conducted in 18
225 men in the Health Professionals Follow-up
Study; the men were aged 40 to 75 years and were
free of diagnosed cardiovascular disease at
blood collection.
Results After adjustment for matched variables,
men deficient in 25(OH)D (≤15 ng/mL [to convert
to nanomoles per liter, multiply by 2.496])
were
at increased risk for MI
compared with those
considered to be sufficient in 25(OH)D (≥30
ng/mL) (relative risk [RR], 2.42; 95% confidence
interval [CI], 1.53-3.84; P < .001 for trend).
Even men with intermediate
25(OH)D levels were at elevated risk relative to
those with sufficient 25(OH)D levels (22.6-29.9
ng/mL: RR, 1.60 [95% CI, 1.10-2.32]; and
15.0-22.5 ng/mL: RR, 1.43 [95% CI, 0.96-2.13],
respectively).
Conclusion Low levels of 25(OH)D are associated
with higher risk of myocardial infarction in a
graded manner, even after controlling for
factors known to be associated with coronary
artery disease.
Author Affiliations: Departments of Nutrition (Drs
Giovannucci and Rimm and Ms Liu) and
Epidemiology (Drs Giovannucci and Rimm), Harvard
School of Public Health, Boston, Massachusetts;
Channing Laboratory, Department of Medicine,
Brigham and Women's Hospital and Harvard Medical
School, Boston (Drs Giovannucci and Rimm); and
Department of Pediatrics, Medical University of
South Carolina, Charleston (Dr Hollis).
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